There are some descriptors that say things like "Only defenses with this Descriptor will protect against them." Supersymmetric is a good example. Since I just had a question from someone over e-mail about how this should work, I'll give my opinion.
If the attack is against an unaware target, invoke the Instant Death Cutscene Rule. If the target is an NPC, um, splitch.
If the target is aware of the attack, their Stringtech value is unavailable. They have to substitute half their Bio score, to represent dodging the shot and their body absorbing the shockwave. (Also, only half of the Bio reserve should be available for this conflict.) Professions like Soldier and Police are still usable.
GMs should use the defender's Nano score to gauge whether they could be aware of the attack. Nano 5 could detect the heat buildup in an Energy weapon. Nano 9 can pick up traces from dark matter weapons. An attack from beyond "line of sight" is practically undetectable, and definitely cause for the IDCR.





